Ketone Ester for type 2 Diabetes
Obesity along with type 2 diabetes mellitus is becoming more frequent in the past 20 years. Chronic disturbances in glucose and lipid levels in plasma increase cardiac morbidity and mortality. Diabetic heart diseases are characterized by metabolic, functional and structural alterations, lead to excess risk of cardiovascular incidents. The ketone bodies are produced normally in the liver from mobilized free fatty acids (FFA) in response to changes in glucose and insulin levels, during fasting.
Circulating ketone bodies are a high energy fuel, that could supply a heart, yet ketosis is often inappropriately feared because high ketone levels are involved in the adverse effects of uncontrolled type 1 diabetes. This misapprehension has overshadowed the therapeutic potential of ketosis resulting from a ketogenic diet, which has been used for over 70 years to treat diabetes. However, the ketogenic diet leads to the increased level of free fatty acids. A better alternative could be an edible ester form of d-beta-hydroxybutyrate [(R)-3-hydroxybutyl (R)-3-hydroxybutyrate] called ∆G, that has been developed in the hope that the ingestion of ∆G drinks would create a novel physiological ketosis for diabetes without elevating FFA. Novel ∆G can be consumed in conjunction with a normal diet, thereby offering the same benefits as the ketogenic diet.
Recent experiments on rats showed that ∆G improves heart energy supply and lipid profile. Thus, the aim of this project is to evaluate if and why the novel ketone ester improves the function, morphology and energetics of the diabetic heart (1) in obese mice and (2) in obese mice after myocardial infarction (3) considering differences related to the gender by introducing both-male & female mice.
The result will contribute to the better understanding of type 2 diabetes pathology and diabetic heart diseases in gender context. Due to the more frequent obesity along with type 2 diabetes in the past 20 years, the results will bring the benefits to the society through better prophylaxis and treatment of motioned civilization diseases.
The proposal was awarded Marie Skłodowska-Curie Actions Seal of Excellence in 2016.
Project Proposal Status:
University of Oxford
Department of Physiology, Anatomy and Genetics
Department of Physiology, Anatomy and Genetics is a pre-clinical department of Division of Medical Sciences of the University of Oxford. University of Oxford is one of the world’s leading Universities in research and education, and reached the 1st place by subject of Anatomy and Physiology in the QS World University Rankings for 2017 and 2018. The University of Oxford was awarded by logo HR Excellence in Research. Department of Physiology, Anatomy and Genetics has received ECU’s Silver Athena Swan award.QS World University Rankings by Subject 2018QS World University Rankings by Subject 2017